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Stoke Therapeutics is seeking a Senior Director, Patient Team Operations & Chief of Staff to the Chief Patient Officer. This strategic and operational leadership role supports the execution of enterprise patient strategy across Commercial, Medical Affairs, and Manufacturing. The individual will act as a trusted advisor and operational partner to the CPO, driving cross-functional alignment, governance, and organizational effectiveness. The position requires a highly collaborative leader with strong biotech/pharmaceutical experience, exceptional communication and organizational skills, and the ability to navigate complex, matrixed environments. Responsibilities include strategic planning, executive material preparation, cross-functional liaison, and operational excellence.
About Stoke:
Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/
Position Summary:
The Senior Director, Patient Team Operations & Chief of Staff to the Chief Patient Officer (CPO) serves as a strategic and operational leader supporting the execution of enterprise patient strategy across Commercial, Medical Affairs and Manufacturing functions. This individual acts as a trusted advisor and operational partner to the CPO, driving cross-functional alignment, governance, execution excellence, and organizational effectiveness.
The role operates at the intersection of strategy and execution, partnering closely with Manufacturing, Medical Affairs, Market Access, Patient Services, Marketing, Regulatory, Clinical Development, Legal/Compliance, and Program Team leadership. The Senior Director will serve as a key liaison between the Patient Organization and cross-functional program teams to ensure integrated planning, decision-making, and operational follow-through across development and commercialization activities.
This position requires a highly collaborative leader with strong biotech/pharmaceutical experience, exceptional communication and organizational skills, and the ability to navigate complex, matrixed environments.
Key Responsibilities:
Strategic & Executive Partnership
Cross-Functional Leadership & Program Team Liaison
Operational Excellence
Communications & Stakeholder Management
Required Skills & Experience:
Required
Preferred
Critical Competencies
Location(s):
Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026. This position is a hybrid position currently based in Bedford and will later be based in Waltham.
Travel:
This position will require approximately 30% travel.
Compensation & Benefits:
At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.
The anticipated salary range for this role is $269,000 - $299,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.
Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).
Culture & Values:
At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.
Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.
Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:
https://www.stoketherapeutics.com/careers/
For more information, visit https://www.stoketherapeutics.com/.
All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.
Stoke participates in E-Verify.